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Literature summary for 2.7.11.22 extracted from

  • Oi, A.; Katayama, S.; Hatano, N.; Sugiyama, Y.; Kameshita, I.; Sueyoshi, N.
    Subcellular distribution of cyclin-dependent kinase-like 5 (CDKL5) is regulated through phosphorylation by dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) (2017), Biochem. Biophys. Res. Commun., 482, 239-245 .
    View publication on PubMed
Search for more literature for 2.7.11.22

Protein Variants

Protein Variants Comment Organism
S308A the mutant enzyme is primarily localized to the nucleus Mus musculus
S308D the mutation mimicking the phosphorylated serine residue by aspartate substitution (S308D) changes CDKL5 localization to the cytosol Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Mus musculus 5829
-
nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide Mus musculus
-
 ADP + beta-nicotinamide D-ribonucleotide
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q3UTQ8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
central nervous system
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide
-
 Mus musculus ADP + beta-nicotinamide D-ribonucleotide
-
 ?

Synonyms

Synonyms Comment Organism
CDKL5
-
 Mus musculus
cyclin-dependent kinase-like 5
-
 Mus musculus
STK9
-
 Mus musculus